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Who played Denny Duquette on ‘Grey’s Anatomy?’

He's since become one of TV's biggest names.

Through seasons 2 and 3 of Grey’s Anatomy, Dr. Isobel Stevens, played by Katherine Heigl, had an ongoing romantic relationship with a heart transplant patient named Denny Duquette. He had been diagnosed with viral cardiomyopathy, which caused his heart to fail, and he had been a long-time patient of Preston Burke, Seattle Grace’s cardiothoracic surgeon.

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Denny Duquette was portrayed by The Walking Dead‘s very own Negan, Jeffrey Dean Morgan, who rose to prominence after appearing on Grey’s Anatomy. Morgan, who’s now 57, is also known for his roles as John Winchester in CW’s Supernatural and Jason Crouse in CBS’ The Good Wife.

During season 2, Denny returns to Seattle Grace on the promise of receiving a new heart, which was supposedly lined up for him. It was during this time that he met Izzie, with whom he formed an instant connection. They flirted often, but it was Izzie who ultimately had to break the news to Denny that he wasn’t getting a heart, therefore he was discharged.

Photo via ABC

He returned to Seattle Grace at a later time due to heart failure. He was tachycardic and in order to slow his heart, the doctors needed to shock it, which stabilized him. While on an LVAD, Denny got to know Izzie better, eventually becoming her boyfriend. This all came to a head when Denny’s next donor heart fell through, so Izzie exacerbated Denny’s condition to move him further up the donor list. She did so by cutting his LVAD wire, causing him to flatline.

As a result, the heart getting shipped to Mercy West Medical Center to be used by Dr. Erica Hahn was redirected to Seattle Grace for Denny. However, after Denny’s surgery, despite the heart functioning properly, a blood clot at the incision point caused him to have a stroke and he died. This left Izzie heartbroken, never able to fully recover from his loss.

After his death, Denny continued to appear as a hallucination to Izzie until the cancerous tumor in her brain was removed.


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Image of Chynna Wilkinson
Chynna Wilkinson
Chynna has been a noteworthy presence within creative media for over seven years. As a self-proclaimed geek driven by a passion for horror, comic books, video games, and modern cinema, she takes pride in doing what she loves. In addition to her personal writing projects, Chynna is also an award-winning screenwriter, published poet, and accomplished academic writer, producing everything from short stories and screenplays to articles, features, and poetry. She enjoys watching anime, horror movies, and animated shows and her life revolves around cinema, video games, and tasteful literature.