Carlie Cooper

This third Spider-Man franchise will feel stale immediately if either Gwen Stacy or Mary Jane Watson are the primary love interests, so we suggest that someone like Carlie Cooper enter the mix. Cooper is friends with Harry Osborn and Gwen Stacy and became one of Peter's key romantic interests after 2007. She eventually learns about Peter's wall-crawling alter-ego which, of course, puts her in imminent danger. Carlie is also eventually injected with the Green Goblin formula and becomes a foe known as Monster. So, a new love interest with a potentially tragic and villainous destiny? Sounds like a superhero soap opera, alright!