2) Kraven The Hunter
Touted as a member of Marc Webb’s ill-fated Sinister Six in the continuation of the Amazing Spider-Man series, Kraven The Hunter is a villain who’s simply crying out for a big screen appearance. He offers so much, and has justifiably been included in some of the Web-Slinger’s greatest comic book tales.
Kraven brings something that few of the other foes on this list can, in that he is able to consistently take the upper hand against Spidey. So far in his movie appearances, we’ve only really seen Peter be truly overpowered once, against Otto Octavius in Spider-Man 2. There were moments we feared for him in the other movies, of course, but only Octavius had to essentially defeat himself after Pete’s reasoned mind work its magic on him.
Kraven would not be so easily dissuaded from his hunt, and would pursue Parker until he could craft his own resolution to the conflict. Fitting him into the larger MCU could also be covered as he could conceivably been ‘watching’ the heroes of The Avengers for some time, biding his time until the right prey enters his domain.