10) Chameleon
Since Tom Holland’s Peter Parker is soon to be making some fairly powerful friends, an enemy that can take their form to attempt to mislead the young hero could be pretty darn dangerous. Over the years, Chameleon has led Peter into some truly unenviable situations, and seeing him have to keep his wits sharp to get out of another would make for an interesting story.
By playing off of the stronger allegiances that Spider-Man ends up taking with him after the events of Captain America: Civil War, Chameleon could lull the hero into a state where he could be manipulated or misled. Peter would have to show maturity above his age and rely on his instincts to know who/what to trust.
So far, we’ve only seen Spidey take on physically challenging foes during his screen-time, so a villain that tests his intelligence would certainly be an intriguing change.