3) Morlun
Not one of Stan Lee and Steve Ditko’s original creations, Morlun is a fairly new villain (he was introduced in the early 2000s when J. Michael Straczynski took over writing duties on The Amazing Spider-Man). However, despite not having decades worth of history, he’s still one of the Marvel Universe’s most fierce and powerful bad guys, and Peter Parker very nearly failed to survive their first encounter as he was truly pushed to and beyond his limits.
Mystical in nature, Morlun arrived on the scene at the time Peter discovered that his powers may be more magic than science based. He relentlessly tracked Spider-Man through New York and started murdering civilians whenever the hero managed to hide to take a rest. With so much focus on Peter’s parents and science in The Amazing Spider-Man movies, focusing on the mystical side of Spidey’s abilities could definitely be a great basis for Marvel’s new trilogy.